Naringenin Inhibits Neointimal Hyperplasia Following Arterial Reconstruction With Interpositional Vein Graft
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چکیده
منابع مشابه
Pretreatment with intraluminal rapamycin nanoparticle perfusion inhibits neointimal hyperplasia in a rabbit vein graft model
PURPOSE Poly lactic-co-glycolic acid nanoparticles (PLGA-NP) are widely used as a biodegradable biomaterial in medicine. Rapamycin-eluting stents have been used for prevention of restenosis during surgery. This study investigated the effect of pretreatment with intraluminal perfusion of carbopol-encapsulated rapamycin-loaded PLGA nanoparticles (RAP-PLGA-NP) on neointimal hyperplasia in a rabbit...
متن کاملNeointimal hyperplasia, vein graft remodeling, and long-term patency.
NEOINTIMAL HYPERPLASIA is generally considered as the major cause of vein graft stenosis and is the leading pathological sign of vein graft disease. Most research on this problem has focused on the inhibition of neointimal growth, based on the hypothesis that the inhibition of neointimal hyperplasia would improve long-term patency of the vein graft. However, the inhibition of cell proliferation...
متن کاملGamma irradiation inhibits neointimal hyperplasia in rats after arterial injury.
BACKGROUND AND PURPOSE Restenosis complicates a significant proportion of endovascular and open vascular procedures such as carotid endarterectomy. In contrast to the primary atheroma, restenosis is characterized by intimal hyperplasia of vascular smooth muscle cells. We hypothesized that gamma radiation would reduce restenosis by limiting intimal hyperplasia after arterial injury. METHODS To...
متن کاملLocally applied cilostazol suppresses neointimal hyperplasia and medial thickening in a vein graft model.
BACKGROUND Pathological changes in vein grafts begin immediately after arterial circulation is applied to the grafts. Chemical mediator stimulation and mechanical strain induce neointimal hyperplasia and medial thickening of the vein grafts, resulting in their failure. We investigated the inhibitory effect of locally applied cilostazol, an inhibitor of cyclic adenosine monophosphate phosphodies...
متن کاملMicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia
Neointima formation is the major reason for vein graft failure. However, the underlying mechanism is unclear. The aim of this study was to determine the role of miR-26a in the development of neointimal hyperplasia of autogenous vein grafts. Using autologous jugular vein grafts in the rat carotid artery as a model, we found that miR-26a was significantly downregulated in grafted veins as well as...
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ژورنال
عنوان ژورنال: Annals of Plastic Surgery
سال: 2010
ISSN: 0148-7043
DOI: 10.1097/sap.0b013e31819b03cd